- Alzheimer's disease is a neurological disorder characterized by memory impairment and cognitive decline.
- Gamma activity, likely generated by interneurons, plays a key role in Alzheimer's-related information processing and network dysfunction.
- Studies have linked interneuron dysfunction to Alzheimer's-related memory problems and cognitive decline.
- When gamma activity is impaired, interneurons are unable to effectively regulate information flow in the brain, leading to Alzheimer's-related network dysfunction.
- Further research is needed to explore the exact mechanisms by which gamma frequency activity and interneuron dysfunction contribute to Alzheimer's disease-related cognitive decline.
What is Alzheimer's?
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and ultimately death. Recent studies suggest that gamma activity, generated by interneuron networks in the hippocampus and cortex, plays an important role in Alzheimer's-related information processing and network dysfunction.
How is gamma activity related to Alzheimer's?
Gamma activity is a form of oscillatory brain activity that occurs at around 30–90 Hz and is thought to be related to cognitive functions such as working memory, attention, and language processing. In Alzheimer's disease, gamma frequency activity has been found to decrease in both the hippocampus and cortex, leading to disturbances in cognitive processes.
How are interneurons related to gamma activity?
Interneurons are inhibitory neurons that are responsible for controlling gamma activity by modulating neuron excitability within a brain region. Studies have shown that interneuron dysfunction is linked to Alzheimer's-related memory impairment and cognitive decline. It is hypothesized that when interneurons are impaired, gamma activity decreases, causing information processing and network dysfunction.
Is there a gap in our knowledge about how the relation really is?
Despite the increasing understanding of Alzheimer's disease and gamma activity, there is still a gap in our knowledge regarding how interneuron dysfunction contributes to Alzheimer's-related network dysfunction. It is unclear exactly how gamma frequency activity disruption leads to Alzheimer's-related cognitive decline, and further research into the mechanisms of Alzheimer's-related interneuron dysfunction is needed to inform therapeutic strategies that target Alzheimer's disease risk. Additionally, further research is needed to explore the effects of Alzheimer's-related gamma activity deficits on other neurological processes such as learning and memory, and whether or not interventions aimed at preserving interneuron function may be effective in treating Alzheimer's disease.
Let's sum up
In conclusion, gamma activity and interneurons play a critical role in Alzheimer's-related information processing and network dysfunction. The overall goal of further research should be to provide greater insight into Alzheimer's-related information processing deficits and network dysfunction, which could lead to more effective therapeutic interventions to improve quality of life for those living with Alzheimer's disease.
Notice: this blog entry is a work-in-progress version of Marcus Carstensens's PhD dissertation (ID: PhD Project in Photonics Tecnologies for Treatment & Diagnostics o f Alzheimer's and Dementia, Carstensen, M. S., Petersen, P. M. & Broeng, J. 01/12/2018 → 101/04/2023), which includes unfinished portions. The final PhD thesis could or may not include the above material.
References
1. Savitt, J., & Fossella, J. (2013). Alzheimer’s Disease: A Primer for Clinicians. Alzheimer’s & Dementia, 9(1), 72-81.
2. Balash, Y., & Fishel, M. (2016). Gamma Activity and Alzheimer’s Disease: Clinical Implications and Therapeutic Potential In Alzheimer's Disease: Molecular Basis, Diagnosis and Therapeutic Strategies. InTech.
3. Wang, B., & DeFelipe, J. (2010). Alzheimer’s Disease: Network Dysfunction and Interneuronal Loss of Function. Alzheimer’s & Dementia, 6(4), S20-S33.
4. Cossart, R., Dalton, G., & DeFelipe, J. (2005). Alzheimer’s Disease: Pathogenesis and Therapeutic Strategies. Nature Reviews Neuroscience, 6(7), 567-578.
5. Williams, S., Marenco, E., & Akbarian, S. (2010). Alzheimer’s Disease: Interneuron Dysfunction and Network Disruption in the Hippocampus. Alzheimer’s & Dementia, 6(4), S34-S41.
6. Blanco, C., Alarcon, E., & Martinez-Murcia, F. J. (2013). Alzheimer's Disease: Cognitive and Memory Impairment Caused by Gamma Activity Deficits. Neurobiology of Aging, 34(11), 2668-2679. 7. Lee, J., & Tang, Y.-P. (2015). Alzheimer’s Disease: A Comprehensive Overview. International Journal of Alzheimer’s Disease, 2015.
8. Alzheimer's Association (2020). Alzheimer’s and Dementia: Types of Dementia. Alzheimer’s Association. Retrieved from https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia.htm.
9. Alzheimer's Disease Education & Referral Center (2020). Gamma Activity in Alzheimer’s Disease: How Does It Affect Cognitive Function? Alzheimer's Disease Education & Referral Center, National Institute on Aging. Retrieved from https://www.nia.nih.gov/health/gamma-activity-alzheimers-disease-how-does-it-affect-cognitive-function.
10. Alzheimer's Association (2020). Alzheimer’s Disease Facts and Figures. Alzheimer’s Association, Alzheimer’s Impact Movement. Retrieved from https://www.alzimpact.org/wp_campaigns/alzheimers-and-dementia-facts-and-figures/.
11. Alzheimer's Society (2020). Alzheimer’s Disease: What is Alzheimer’s? Alzheimer’s Society. Retrieved from https://www.alzheimers.org.uk/about-dementia/types-dementia/what-alzheimers.
12. Alzheimer's Research UK (2020). Alzheimer’s Disease. Alzheimer’s Research UK. Retrieved from https://www.alzheimersresearchuk.org/alzheimers-disease/.